Research view
Title: | Catechol-O-methyltransferase gene polymorphisms in Saudi cases with schizophrenia |
Author: | Ashraf Tantawy, Abduhamid Al-Yahia, Yasser Raya,Abdurrahman Al-Mohaimeed, Ahmad Settin |
Abstract: |
Background
This work was conducted to test for the association of genetic polymorphisms of catecholO-methyltransferase
(COMT) with the susceptibility and clinical patterns of schizophrenia
among Saudi patients.
Participants and methods
This is a case–control study involving 79 patients fulfilling the ICD-10 criteria of schizophrenia
and 82 healthy controls. Patients were interviewed by different tools, which included the
Diagnostic Interview for Genetic Studies (DIGS/V4.0), the Positive and Negative Symptoms
Scale (PANSS), and the World Health Organization Disability Assessment Schedule
(version 2.0) (WHO/DAS II). All patients and controls were screened for COMT G >A gene
polymorphisms using the real-time PCR technique.
Results
Frequencies of all genetic variants of COMT G >A [V158M] did not show a significant difference
on comparing cases with controls (P > 0.05). Comparing the frequencies of genetic variants
in cases having positive parental consanguinity and a family history of schizophrenia or other
mental illnesses with those without a history also showed nonsignificant results (P > 0.05). A
stratified analysis related to severity scores and associated clinical illnesses also showed a
nonsignificant difference (P > 0.05).
Conclusion
Polymorphism related to COMT G >A was not associated with the susceptibility and the severity
of schizophrenia among Saudi cases.
Keywords:
catechol-O-methyltransferase, gene polymorphism, Saudi Arabia, schizophrenia
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Journal: | Egyptian Journal of Psychiatry 2015, 36:118–123 |
Text: | |
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