Research view
Title: | A longitudinal study of psychiatric consequences of hepatitis C virus patients receiving interferon therapy |
Author: | Victor S. Mikhael, Hussien E. El-Sheikh, Mohamed M.E. Atta, Mohamed M. El-Hamady and Shorouk F. Abd-Elmksoud |
Abstract: |
Objective
A growing body of evidence suggests that patients infected with hepatitis C virus
(HCV) have a high prevalence of psychiatric disorders. Antiviral treatment, particularly
interferon (IFN), may induce an increase in the incidence of psychiatric symptoms
observed in HCV patients.
Aim
This study aimed to identify the possible psychiatric complications in patients infected
chronically with HCV and follow up these complications on treatment with pegylated
IFN plus ribavirin.
Patients and methods
This is a longitudinal follow-up, comparative (case–control) study conducted on 90
patients, all of whom were subjected to a semistructured interview, psychometric
assessment by International Classification of Diseases-10 Symptom Checklist for
Mental Disorder version 1.1 for psychiatric evaluation, laboratory investigations to
exclude decompensate liver cases, liver biopsy, and abdominal ultrasonography.
Results
HCV prevalence was found to be significantly higher in the age group of 30–40 years.
Results of the International Classification of Diseases-10 symptom checklist showed
prevalence of psychiatric complications linked to HCV infection before therapy, which
included generalized anxiety disorder; these complications increased after treatment,
such as mixed anxiety and depression and moderate depression. HCV infection
independent of IFN therapy and hepatitis B virus infection caused mild depression and
mixed anxiety and depression.
Recommendations
HCV-related psychiatric consequences and HCV therapy-related psychiatric
complications should be included in the differential diagnosis of patients, and patients
should be assessed through consultation liaison psychiatry.
Keywords:
hepatitis C virus, interferon therapy, psychiatric consequences
|
Journal: | Middle East Curr Psychiatry 24:145–155 |
Text: | |
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