Research view
Title: | Correlates of brain derived neurotrophic factor in children with attention deficit hyperactivity disorder: A case-control study |
Author: | Hala Taha, Eman Elsheshtawy, Soheir Ibrahim Mohamed, Omnia Al-Azazzy, Mohamed Elsayed and Salah Al Sayed Ibrahim |
Abstract: |
Background
Brain derived neurotrophic factor (BDNF) appears to intervene in the pathogenesis
and treatment response in Attention deficit hyperactivity disorder (ADHD), based on
the conceptualization of ADHD as a neurodevelopmental disorder and the
importance of the BDNF for normal neural development.
Aim
To estimate the difference in the serum level of BDNF in children diagnosed with
ADHD and normal control, find its clinical correlates and to search which factors
could predict abnormal level of BDNF.
Subjects and methods
A case control study was done on 35 child newly diagnosed untreated ADHD,
control group of 30 healthy children. All were subjected to IQ test (Stanford-Binet),
Conner’s test to assess severity of different symptoms. Blood sample to determine
the level of BDNF.
Results
Serum level BDNF was significantly higher in children with ADHD (0.1596±0.0909
ngm). BDNF was positively correlated with cognitive problems (r=0.345) and
negatively correlated with age and IQ (r=−0.399, −0.383 respectively).
Predictors for high level of BDNF were age (beta=−0.368), IQ (beta=−0.368)
and inattention (beta=0.422).
Conclusion
High serum level of BDNF in children with ADHD could have a role in the etiology of
ADHD, affecting cognition and intelligence. The presence of inattention and low
intelligence can predict high level of BDNF.
Keywords:
ADHD, BDNF, Egypt, intelligence, predictors
|
Journal: | Egypt J Psychiatr 38:159–163. 2017 |
Text: | |
Download |