Research view
Title: | Metabolic syndrome in psychiatric patients (comparative study) |
Author: | Fatma A. Mousa, Hani H. Dessoki, Sarah M. El Kateb, Ahmed A. Ezzat and Mohamed R. Soltan |
Abstract: |
Background
It is generally estimated that metabolic syndrome (MetS) is especially common in
patients with severe mental illness, with a high prevalence ranging from 30 to 60%
for schizophrenic and bipolar disorders, which predispose them to further medical
complications up to premature death.
Objective
The aim of this study was to compare the prevalence of MetS in patients with major
depressive disorder (MDD), schizophrenic patients, and healthy general individuals,
and to assess the relation between cortisol levels and presence of MetS.
Patients and methods
The study included 120 participants (40 patients with drug-naive MDD, 40 patients
with drug-naive schizophrenia, and 40 healthy individuals who served as the control
group). Full history was taken. Blood pressure and waist circumference (WC) were
measured and BMI was calculated. Laboratory investigations were carried out,
including fasting blood glucose (FBG), serum triglycerides, serum high-density
lipoprotein, and a morning level of serum cortisol.
Results
The study revealed a similar prevalence of MetS in the MDD and the schizophrenic
group (27.5%) compared with a prevalence of 22.5% in the control group. The WC
and the BMI were significantly higher in the MetS patients of the MDD and the
schizophrenic group compared with those of the control group. FBG was
significantly higher among MetS patients in the MDD group as compared with
those in the schizophrenic and the control group. Cortisol level was significantly
higher in MetS patients in the MDD and the schizophrenic group as compared with
those in the control group.
Conclusion
The prevalence of MetS is higher in MDD and schizophrenic patients than in the
general population, and is related to high WC, BMI, FBG, and serum cortisol.
Hence, screening of such patients for metabolic disturbances is recommended.
Keywords:
major depressive disorder, metabolic syndrome, schizophrenia
|
Journal: | Egypt J Psychiatr 38:179–191. 2017 |
Text: | |
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