Psychiatry Research EG

This immunologic study of 43 intravenous herion abusers, was carried out to explore the possible existence of pathogenic factors which may trigger the abnormalities. Serum concentrations of immunoglobulins IgM, 19G, and IgA were determined, and compared to those of two control groups.
High significant elevations of IgM (p < O.Ol), and significant increase of IgG and IgA (p < 0.05) were detected in parenteral herion,ahusers. The associated immunodeficiencies in herion abusers may he initiated by the action of the drug and adulterants and become aggravated during the course of abuse by malnutrition and infection through needle using and sharing. The data reveal the importance of considering the virological status besides the toxicological investigations of the current abusers of narcotics. Further research is recommended.