Research view
| Title: | Gamma-secretase as a pharmacological target in Alzheimer disease research: when, why and how? |
| Author: | Ziani-Cherif C, Mostefa-Kara B, Brixi-Gormat FZ |
| Abstract: |
Alzheimer disease (AD) is characterized by excessive deposition of amyloid
beta-peptides (Abeta peptides) in the form of senile plaques as well as
neurofibrillary tangles (NFTs) in the brain. In the amyloidogenic pathway, the
amyloid-beta precursor pro
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| Journal: | Curr Pharm Des. 2006;12(33):4313-35 |