Psychiatry Research EG

Agranulocytosis is an idiosyncratic reaction that usually occurs in the first 3–4 weeks of treatment with psychotropic drugs, particularly with clozapine. All psychotropic drugs have been associated with blood dyscriasis [1&2]. White blood cells (WBCs) are affected most commonly resulting in neutropenia (neutrophils < 1500 ml) or agranulocytosis (neutrophils < 500 ml). The drug-induced dyscriasis might be caused by direct toxic effect on bone marrow, peripheral destruction, or antibody formation against hematopoietic cells or its precursors. Keywords: agranulocytosis, neutropenia, typical and atypical antipsychotics