
Research view
Title: | Efficacy of repetitive transcranial magnetic stimulation in drug-resistant schizophrenics |
Author: | Adel A. Badawy and Amr A. Haiba |
Abstract: |
Background
Despite the advances in pharmacological treatment of schizophrenia, the results are
unsatisfactory. Therefore, the search for new antipsychotic drugs and the development
of novel treatments for schizophrenia are critical. Transcranial magnetic stimulation is
one of the tools that may help schizophrenic patients.
Aim of the study
To evaluate the efficacy of repetitive transcranial magnetic stimulation (r-TMS) in the
treatment of drug-resistant schizophrenic patients.
Patients and methods
This study included 40 drug-resistant schizophrenic patients. In a random, doubleblind
placebo-controlled study, 30 patients were treated by 15 r-TMS sessions to both
the left dorsolateral prefrontal cortex and the left temporoparietal cortex for 3 weeks.
Ten patients were randomly subjected to sham stimulation (placebo group). Before
and after the treatment sessions, all patients were assessed using the Positive and
Negative Syndrome Scale, the Calgary Depression Scale for Schizophrenia, and
cognitive tests.
Results
r-TMS could significantly improve only the negative symptoms. The positive symptoms,
general psychopathology, and cognitive functions did not show any significant
changes. The sham (placebo group) did not show any significant changes in
schizophrenic symptoms and cognitive functions.
Conclusion
r-TMS can be a useful add-on treatment that helps to improve negative schizophrenic
symptoms in drug-resistant patients.
Keywords:
negative syndrome, resistant schizophrenics, transcranial magnetic stimulation
|
Journal: | Egyptian Journal of Psychiatry 2013, 34:172–176 |
Text: | |
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