
Research view
Title: | Cognitive decline in different delirium subtypes and the associated change in the biomarker S100B serum level |
Author: | Nabil R. Mohamed, Lamiaa G. El Hamrawy, Ayman K. Abdel-Hamid,Afaf Z. Ragab, Mohamed S. Abdel-Shafy |
Abstract: |
Objectives
This study was designed to assess the cognitive decline in different delirium subtypes and the
change in the level of serum S100B, with determination of the outcome of delirium.
Background
Delirium involves a wide range of cognitive disturbances across its different subtypes. The
serum S100B level is high in delirious patients and plays a role in the process of learning and
memory. The outcome of delirium differs according to delirium subtypes.
Participants and methods
This study enrolled 35 delirious patients (group A) and two control groups. Group B comprised
10 patients with disease but without delirium. Group C comprised 10 normal healthy individuals.
All participants were subjected to the Delirium Symptom Interview scale, the Cognitive Test
for Delirium, the Delirium Motor Subtype Scale, and the Trail Making Test parts A and B, and
the level of serum S100B was measured. About 17 delirious patients were followed up after
1 month to assess the cognitive decline and the mortality rate.
Results
The level of cognitive dysfunction in delirious patients was signifi cantly higher than that in the two
control groups (group B and group C). The level of cognitive dysfunction was not signifi cantly
different among the four delirium subtypes. Attention impairment occurred in 96% of the patients,
and the less affected cognitive domain was comprehension, which occurred in 77% of the patients.
The level of serum S100B was signifi cantly higher in delirious patients compared with the two
control groups, but it was not signifi cantly different among the delirium subtypes. After 1 month,
the hypoactive subtype was associated with more cognitive dysfunction and a high mortality rate.
Conclusion
Cognitive decline occurs in delirious patients, but this decline was not signifi cantly different
among the delirium subtypes. The most affected cognitive domain was attention and the least
affected one was comprehension. Delirium was associated with a high level of serum S100B,
but this level was not signifi cantly different among the delirium subtypes. The hypoactive
subtype was associated with a poor outcome.
Keywor ds :
cognitive decline, delirium subtypes, serum S100B
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Journal: | Egyptian Journal of Psychiatry 2015, 36:14–20 |
Text: | |
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