Psychiatry Research EG

Background The perimenopause marks a major life transition for women, an end to the childbearing years and cessation of menses. Women frequently face a number of major life stressors during the years leading up to menopause. Aim This study aimed to explore the biopsychosocial aspects of perimenopause, to study the distribution of menopausal symptoms in an urban versus a rural community, and to study the psychosocial profi le of women with psychiatric disorders during the perimenopausal period and their impact on quality of life to evaluate their attitude toward menopause and its relation to the psychiatric disorders, and to focus on the possible relationship between estradiol level and psychiatric disorders in perimenopausal women. Patients and methods This study enrolled 50 perimenopausal women and 20 premenopausal women as a control group. Tools of the study We used the following tools: Structured Clinical Interview of DSM-IV, Stressful Life Events Scale, the Arabic version of Greene Climacteric Scale and Menopausal Symptom Checklist, the Quality of Life Scale for Menopausal Women, Attitude Towards Menopause, the Hamilton Depression Rating Scale, the Hamilton Anxiety Rating Scale, the Sleep Questionnaire, and laboratory investigations including determination of follicle stimulating hormone serum level and serum estradiol level. Results In this study, the perimenopausal group had signifi cantly (P < 0.001) greater stressful life events than premenopausal women (66% of perimenopausal women were at a defi nite risk for illness and 34% were at a moderate risk for illness). Perimenopausal women with psychiatric disorders had signifi cantly greater stressful life events than those without psychiatric disorders. We also found that 36 (72%) perimenopausal women had signifi cantly (P < 0.01) positive attitude compared with fi ve (25%) premenopausal women. Perimenopausal women with psychiatric disorders had greater severity of menopausal symptoms (highly signifi cant in hot fl ushes). Perimenopausal women with psychiatric disorders had poor quality of life and marked psychological limitations. In the present study, risk factors for patients with major depressive disorder were a family history of mood disorder, vasomotor symptoms, and stressful life events. Risk factors for generalized anxiety disorder were a family history of generalized anxiety disorder (GAD) and vasomotor symptoms. Conclusion It is important to assess the psychosocial profi le, women’s attitude toward menopause, menopausal symptoms, and screening for psychiatric disorders for better quality of life and better outcome. Keywor ds : perimenopause, psychiatric disorders, quality of life