Research view
Title: | Cortisol and its effects on cognitive function in a sample of Egyptian school-aged children with attention-deficit hyperactivity disorder |
Author: | Omneya Ibrahim, Wafaa El-lithy, Khaled Abd El-Moez |
Abstract: |
Background
Several studies have suggested that cortisol level influences the development and functioning
of the brain in children and that it is implicated in a variety of processes including memory
and attention.
Objective
This study was conducted to investigate the relation between cortisol level in children with
attention-deficit/hyperactivity disorder (ADHD) and their cognitive function profile.
Methods
The participants of the study, held in Suez Canal University Hospital in Ismailia, were
recruited from among those attending the childhood and adolescent psychiatry clinic.
They were divided into two groups, the ADHD group [diagnosis based on Diagnostic
and Statistical Manual of Mental Disorders, 4th ed., text revision (DSM-IV-TR) through
a structured clinical interview], composed of 43 children (pure ADHD children with no
comorbid conditions), and the control group, composed of 31 typically developing children.
All of them participated voluntarily in this study. The participants’ ages ranged from 6 to
12 years; both sexes were included. Early morning awakening salivary cortisol levels were
collected on two different days 2 months apart. The Stanford–Binet intelligence test 4th
edition, the Wisconsin Card Sorting Test, Conner’s test, and the child behavioral checklist
were administered on all participants.
Results
Early morning salivary cortisol levels in both groups showed a statistically significant difference.
Comparison shows that there was a statistically significant difference in the mean total score
and the mean subdomain score of Stanford–Binet intelligence test 4th edition and Wisconsin
Card Sorting Test (total number of errors, perseverative errors) between ADHD children and
the comparison group. These results were positively correlated with decrease in mean cortisol
awakening response.
Conclusion
There are significant associations between salivary cortisol levels and cognitive and executive
function impairment in children with ADHD.
Keywords:
attention-deficit/hyperactivity disorder, cortisol, executive functions, school-aged children
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Journal: | Egyptian Journal of Psychiatry 2016, 37:41–45 |
Text: | |
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