Research view
Title: | Association of the type 2 diabetes mellitus susceptibility gene (IGF2BP2) with schizophrenia in an Egyptian sample |
Author: | Mohamed El Sayed El Taweel and Ahmed Abdalla Ali |
Abstract: |
Introduction
A link between schizophrenia and diabetes has been known for over a century, long
before the use of antipsychotic medications. Type 2 diabetes mellitus is an important
contributor to mortality and morbidity in this condition. Insulin growth factor 2 mRNA
binding protein 2 (IGF2BP2) genetic variants rs4402960 and rs1470579 have been
implicated in the etiology of type 2 diabetes mellitus in Egyptians. It is possible that
both disorders share a common genetic susceptibility.
Aim
The current study aimed to explore single-nucleotide polymorphism 2 (IGF2BP2)
polymorphisms in a sample of Egyptian first-episode schizophrenic patients and
healthy controls and to study its potential correlation with severity of psychopathology.
Patients and methods
Thirty male patients with first-episode schizophrenia according to International
Classification of Diseases-10 criteria and 30 healthy individuals were genotyped for
IGF2BP2 rs4402960 and rs1470579 variant polymorphisms. Laboratory assessment
included plasma glucose, glycated hemoglobin (HbA1c), triglycerides, total
cholesterol, and high-density lipoprotein cholesterol (HDL-c). Psychological measures
included Mini-International Neuropsychiatric Interview, Positive and Negative
Syndrome Scale, and an Interview for the Retrospective Assessment of the Onset of
Schizophrenia instrument. General Health Questionnaire was applied in healthy
individuals.
Results
There was a statistically significant difference between the two groups as regards 2
mRNA binding protein 2 (IGF2BP2) genetic variants rs4402960 and rs1470579
allelic frequency and distribution (Po0.05). There was a statistically significant
difference between the two groups as regards the plasma/serum levels of glucose,
HbA1c, total cholesterol, and HDL-c (Po0.05). There was a statistically significant
positive correlation between rs4402960 variant polymorphism and plasma glucose
level, HbA1c, and Positive and Negative Syndrome Scale (positive symptom scores)
(Po0.05). There was a statistically significant positive correlation between rs1470579
variant polymorphism and plasma levels of glucose, HbA1c, triglycerides, and positive
symptom scores (Po0.05). There was a statistically significant negative correlation
between rs1470579 variant polymorphism and plasma HDL-c level (Po0.05).
Conclusion
Our data support the notion that both schizophrenia and type 2 diabetes mellitus may
be linked by shared genetic associates, and hence diabetes may not merely be a
comorbid condition.
Keywords:
IGF2BP2 genetic variants, Egyptian, schizophrenia
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Journal: | Middle East Curr Psychiatry 24:55–62 |
Text: | |
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